Chung-Chih Kuo
Current Position
Associate Professor, Tzu Chi University, Hualien, Taiwan
Department of Physiology, School of Medicine
Education
Ph.D., 2005 National Taiwan University, Taipei, Taiwan
Institute of Zoology, College of Life Science
M.S., 1996, National Taiwan Normal University, Taipei, Taiwan
Institute of Biology, College of Science
B.S., 1994, National Sun Yat-Sen University, Kaohsiung, Taiwan
Department of Biology, College of Science
Employment
Aug. 2009 - Jan. 2015, Assistant Professor
Department of Physiology, School of Medicine, Tzu Chi University
Aug. 2006 - July. 2009, Assistant Professor
Institute of Neuroscience, Tzu Chi University
Aug. 2005 - July. 2006, Postdoctoral fellow
Institute of Zoology, College of Life Science, National Taiwan University
Apr. 2004 – Oct. 2004, Research associate
Department of Anatomy, University of Mississippi medical center
Aug. 2000- Apr. 2004, Teaching Assistant
Institute of Zoology, College of Life Science, National Taiwan University
Teaching assistant for animal physiology laboratory course
Aug. 1998 - Jul. 2000, Administrative Teaching Assistant
Department of Biology, College of Science, National Taiwan Normal
University
Sep. 1994 - June. 1996, Teaching Assistant
Department of Biology, College of Science, National Taiwan Normal
University
Teaching assistant for animal physiology laboratory course
Publications
Journal articles
Chen, H.H., Chiang, Y.C., Yuan, Z.F., Kuo, C.C., Lai, M.D., Hung, T.W., Ho, I.K., Chen, S.T.* (2015) Buprenorphine, methadone, and morphine treatment during pregnancy: behavioral effects on the offspring in rats. Neuropsychiatric Disease and Treatment 11, 609-18.
Chiou, R.J., Kuo, C.C., and Yen, C.T. (2014). Comparisons of terminal densities of cardiovascular function-related projections from the amygdala subnuclei. Autonomic Neuroscience 181, 21-30.
Chiou, R.J., Chang, C.W., and Kuo, C.C. (2013). Involvement of the periaqueductal gray in the effect of motor cortex stimulation. Brain Research 1500, 28-35.
Shao, P.C., Tseng, W.T., Kuo, C.C., Shann, W.C., Tsai, M.L., and Yen, C.C. (2013). Effects of spike sorting error on the granger causality index. Neural Networks 46, 249-259.
Chiou, R.J., Lee, H.Y., Chang, C.W., Lin, K.H., and Kuo, C.C. (2012). Epidural motor cortex stimulation suppresses somatosensory evoked potentials in the primary somatosensory cortex of the rat. Brain Research 1463, 42-50.
Yu, Z.E., Kuo, C.C., Chou, C.H., Yen, C.T., and Chang, F. (2011). A machine learning approach to classify vigilance states in rats. Expert Systems with Applications 38, 10153-10160.
Chiou, R.J., Kuo, C.C., Liang, K.C., and Yen, C.T. (2009). State-dependent amygdala stimulation-induced cardiovascular effects in rats. Chinese Journal of Physiology 52, 432-440.
Kuo, C.C., Chiou, R.J., Liang, K.C., and Yen, C.T. (2009). Differential involvement of the anterior cingulate and primary sensorimotor cortices in sensory and affective functions of pain. Journal of Neurophysiology 101, 1201-1210.
Kuo, C.C., Chen, J.H., Tsai, C.Y., Liang, K.C., and Yen, C.T. (2005). Bold signals correlate with ensemble unit activities in rat's somatosensory cortex. Chinese Journal of Physiology 48, 200-209.
Kuo, C.C., and Yen, C.T. (2005). Comparison of anterior cingulate and primary somatosensory neuronal responses to noxious laser-heat stimuli in conscious, behaving rats. Journal of Neurophysiology 94, 1825-1836.
Tsai, M.L., Kuo, C.C., Sun, W.Z., and Yen, C.T. (2004). Differential morphine effects on short- and long-latency laser-evoked cortical responses in the rat. Pain 110, 665-674.
Book chapter
Organizational affilications
Research Interests
The focus of my recent research includes the study of the mechanism of motor cortex stimulation-induced analgesia, the development of neuronal responses induced by addiction drug, and the neural basis of fear learning, memory, and expression. The general strategy used in our lab is to identify behavior phenotype by observation and to record neuronal activities in the region of interests to establish the relationship between behavior and neural activity. For the study of motor cortex stimulation-induced analgesia, we use the cortical evoked potential in primary somatosensory cortex as index to establish the animal model of motor cortex stimulation-induced analgesia and to explore the role of dopaminergic neurons in periaqueductal gray in this phenomenon. For the study of addiction drug, the neuronal activities were recorded with multiple channel recording system in the brain regions of reward circuitry to investigate the acute and chronic effect of addiction drug on neuronal and behavioral responses. In addition, the extend fear circuitry would be explored with multiple approaches including lesion, pharmacology, and anatomical tracing.
Current Position
Associate Professor, Tzu Chi University, Hualien, Taiwan
Department of Physiology, School of Medicine
Education
Ph.D., 2005 National Taiwan University, Taipei, Taiwan
Institute of Zoology, College of Life Science
M.S., 1996, National Taiwan Normal University, Taipei, Taiwan
Institute of Biology, College of Science
B.S., 1994, National Sun Yat-Sen University, Kaohsiung, Taiwan
Department of Biology, College of Science
Employment
Aug. 2009 - Jan. 2015, Assistant Professor
Department of Physiology, School of Medicine, Tzu Chi University
Aug. 2006 - July. 2009, Assistant Professor
Institute of Neuroscience, Tzu Chi University
Aug. 2005 - July. 2006, Postdoctoral fellow
Institute of Zoology, College of Life Science, National Taiwan University
Apr. 2004 – Oct. 2004, Research associate
Department of Anatomy, University of Mississippi medical center
Aug. 2000- Apr. 2004, Teaching Assistant
Institute of Zoology, College of Life Science, National Taiwan University
Teaching assistant for animal physiology laboratory course
Aug. 1998 - Jul. 2000, Administrative Teaching Assistant
Department of Biology, College of Science, National Taiwan Normal
University
Sep. 1994 - June. 1996, Teaching Assistant
Department of Biology, College of Science, National Taiwan Normal
University
Teaching assistant for animal physiology laboratory course
Publications
Journal articles
Chen, H.H., Chiang, Y.C., Yuan, Z.F., Kuo, C.C., Lai, M.D., Hung, T.W., Ho, I.K., Chen, S.T.* (2015) Buprenorphine, methadone, and morphine treatment during pregnancy: behavioral effects on the offspring in rats. Neuropsychiatric Disease and Treatment 11, 609-18.
Chiou, R.J., Kuo, C.C., and Yen, C.T. (2014). Comparisons of terminal densities of cardiovascular function-related projections from the amygdala subnuclei. Autonomic Neuroscience 181, 21-30.
Chiou, R.J., Chang, C.W., and Kuo, C.C. (2013). Involvement of the periaqueductal gray in the effect of motor cortex stimulation. Brain Research 1500, 28-35.
Shao, P.C., Tseng, W.T., Kuo, C.C., Shann, W.C., Tsai, M.L., and Yen, C.C. (2013). Effects of spike sorting error on the granger causality index. Neural Networks 46, 249-259.
Chiou, R.J., Lee, H.Y., Chang, C.W., Lin, K.H., and Kuo, C.C. (2012). Epidural motor cortex stimulation suppresses somatosensory evoked potentials in the primary somatosensory cortex of the rat. Brain Research 1463, 42-50.
Yu, Z.E., Kuo, C.C., Chou, C.H., Yen, C.T., and Chang, F. (2011). A machine learning approach to classify vigilance states in rats. Expert Systems with Applications 38, 10153-10160.
Chiou, R.J., Kuo, C.C., Liang, K.C., and Yen, C.T. (2009). State-dependent amygdala stimulation-induced cardiovascular effects in rats. Chinese Journal of Physiology 52, 432-440.
Kuo, C.C., Chiou, R.J., Liang, K.C., and Yen, C.T. (2009). Differential involvement of the anterior cingulate and primary sensorimotor cortices in sensory and affective functions of pain. Journal of Neurophysiology 101, 1201-1210.
Kuo, C.C., Chen, J.H., Tsai, C.Y., Liang, K.C., and Yen, C.T. (2005). Bold signals correlate with ensemble unit activities in rat's somatosensory cortex. Chinese Journal of Physiology 48, 200-209.
Kuo, C.C., and Yen, C.T. (2005). Comparison of anterior cingulate and primary somatosensory neuronal responses to noxious laser-heat stimuli in conscious, behaving rats. Journal of Neurophysiology 94, 1825-1836.
Tsai, M.L., Kuo, C.C., Sun, W.Z., and Yen, C.T. (2004). Differential morphine effects on short- and long-latency laser-evoked cortical responses in the rat. Pain 110, 665-674.
Book chapter
- Shaw FZ, Kuo CC, Tsai ML, Yen CT (2009) Cerebral cortical responses to nociceptive laser heat stimulation in conscious behaving rats. In: Nociceptive and Neuropathic Pain: Mechanisms and Treatments (Shyu BC, ed), pp 105-119. Kerala, India: Research Signpost.
Organizational affilications
- Society for Neuroscience (SFN)
- The Chinese Physiological Society
- Basic Neuroscience Society of R.O.C.
Research Interests
The focus of my recent research includes the study of the mechanism of motor cortex stimulation-induced analgesia, the development of neuronal responses induced by addiction drug, and the neural basis of fear learning, memory, and expression. The general strategy used in our lab is to identify behavior phenotype by observation and to record neuronal activities in the region of interests to establish the relationship between behavior and neural activity. For the study of motor cortex stimulation-induced analgesia, we use the cortical evoked potential in primary somatosensory cortex as index to establish the animal model of motor cortex stimulation-induced analgesia and to explore the role of dopaminergic neurons in periaqueductal gray in this phenomenon. For the study of addiction drug, the neuronal activities were recorded with multiple channel recording system in the brain regions of reward circuitry to investigate the acute and chronic effect of addiction drug on neuronal and behavioral responses. In addition, the extend fear circuitry would be explored with multiple approaches including lesion, pharmacology, and anatomical tracing.